Gü1303

• Description :

  Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK) . Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

• CAS Number :

  [1043922-53-7]

• UNSPSC :

  12352005

• Target :

  Cathepsin

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/g-1303.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CN(N(C([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)C)C#N

• Molecular Formula :

  C20H22N4O3

• Molecular Weight :

  366.41

• References & Citations :

  [1]Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :515-526.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cathepsin K