Deac-SS-Biotin

• Description :

  Deac-SS-Biotin is a potent antitumor agent with improved tumor targeting effects and reduced off-target toxicities. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity[1].

• UNSPSC :

  12352005

• Target :

  Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/deac-ss-biotin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [H][C@]12NC(N[C@]1(CS[C@H]2CCCCC(OCCSSCCOC(N[C@H]3CCC4=C(C5=CC=C(C(C=C53)=O)OC)C=C(C(OC)=C4OC)OC)=O)=O)[H])=O

• Molecular Formula :

  C35H45N3O10S3

• Molecular Weight :

  763.94

• References & Citations :

  [1]Wang C, et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :411-420.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported