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Deac-SS-Biotin

CAT: 0804-HY-144793Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144793Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Deac-SS-Biotin is a potent antitumor agent with improved tumor targeting effects and reduced off-target toxicities. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity[1].
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/deac-ss-biotin.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12NC(N[C@]1(CS[C@H]2CCCCC(OCCSSCCOC(N[C@H]3CCC4=C(C5=CC=C(C(C=C53)=O)OC)C=C(C(OC)=C4OC)OC)=O)=O)[H])=O
Molecular Formula
C35H45N3O10S3
Molecular Weight
763.94
References & Citations
[1]Wang C, et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :411-420.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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