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TRK/ALK-IN-1

CAT: 0804-HY-144732Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144732Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRK/ALK-IN-1 (compound 21) is a potent and dual inhibitor of TRK and ALK. TRK/ALK-IN-1 in the enzymatic assays is in good accordance with anti-proliferative activity with IC50 values of 2.2, 9.3 and 38 nM towards TRKA, ALKWT and ALKL1196M, respectively. TRK/ALK-IN-1 has the potential for the research of cancer diseases[1].
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trk-alk-in-1.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)C2=CC=C(C=C2C(N3CCSCC3)=O)NC([C@@H]4CCCN4C5=NC(NC6=CC(F)=CC(F)=C6)=NC=C5Cl)=O
Molecular Formula
C31H35ClF2N8O2S
Molecular Weight
657.18
References & Citations
[1]Li T, et al. Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects. Bioorg Med Chem. 2021 Oct 1;47:116396.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA

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