Pan-HER-IN-1

CAT: 0804-HY-144676Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-144676Size:1 Each

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Description

Pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities[1].

CAS Number

1639040-94-0

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pan-her-in-1.html

Solubility

10 mM in DMSO

Smiles

C=CC(NC1=CC=C2N=CN=C(C2=C1)NC3=CC4=C(NC=C4Br)C=C3)=O

Molecular Formula

C19H14BrN5O

Molecular Weight

408.25

References & Citations

[1]Tang Q, et al. Discovery of N- (3-bromo-1H-indol-5-yl) -quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors. Eur J Med Chem. 2022 Apr 5;233:114249.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1; ErbB2/HER2; ErbB4/HER4

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HY-159912	Pan-TEAD-IN-1
HY-101295-01	Pan-RAS-IN-1
HY-148098-01	Pan KRas-IN-1
HY-101295R	Pan-RAS-IN-1 (Standard)
HY-162960-01	Pan-KRAS degrader 1
HY-168671	Pan-KRAS ligand 1
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MBS5804736	pan-HER-IN-1
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MBS1229712-01	Recombinant Caenorhabditis elegans Protein her-1 (her-1)
GTR17963897	Her-1 Antibody
SM-101010-5	Inhibitor of EGFR/HER family (Her1, Her2, Her3 or Pan Her-inhibitor) (BMS-59926/AC480, Mol wt 5671, >99%)
030295	HER-2
299230	Rae-1 pan
GTR19234828-01	Pan-HCN-IN-1
GTR17964088	Pan-1 Antibody
C01512-01	Pan-RAS-IN-1

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