JH-XIV-68-3

JH-XIV-68-3

• CAS Number: 2426628-29-5
• UNSPSC Description: JH-XIV-68-3 is a selective macrocyclic inhibitor of DYRK1A/B. JH-XIV-68-3 displays selectivity for DYRK1A and close family member DYRK1B in biochemical and cellular assays. JH-XIV-68-3 demonstrates antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines[1].
• Target Antigen: DYRK
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/jh-xiv-68-3.html
• Solubility: 10 mM in DMSO
• Smiles: FC(F)(F)C1=NN2C=C1C3=CNC4=NC=C(C=C43)C5=C(C#N)N(C)N=C5CN(C)C(CCC2)=O
• Molecular Weight: 468.43
• References & Citations: [1] Powell CE, et al. Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett. 2022;13(4):577-585.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported