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TRPC5-IN-4

CAT: 0804-HY-144429Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144429Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRPC5-IN-4 is potent and safe TRPC inhibitor with IC50 value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD) [1].
CAS Number
[2762315-39-7]
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/trpc5-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(N2CCC3=C(N=CN=C3OC4=C(C=C(C=C4)F)C(F)(F)F)C2)=C1Cl)=O
Molecular Formula
C18H11ClF4N4O3
Molecular Weight
442.75
References & Citations
[1]Zhang Z, Chen L, Tian H, et al. Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors. Bioorg Med Chem Lett. 2022;61:128612.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPC4; TRPC5

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