BLK-IN-1

• Description :

  BLK-IN-1 (compound 1) is a selective and covalent inhibitor of B-Lymphoid tyrosine kinase (BLK) and BTK, with IC50s of 18.8 nM and 20.5 nM, respectively. BLK-IN-1 can be used for the research of cancer[1].

• UNSPSC :

  12352005

• Target :

  Btk

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/blk-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CN=C(NC2=CC=CC(NC(C=C)=O)=C2)N=C1)C3=CC(NC(C4=CC=CC(C(F)(F)F)=C4)=O)=CC=C3C

• Molecular Formula :

  C29H23F3N6O3

• Molecular Weight :

  560.53

• References & Citations :

  [1]Fu T, et, al. Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK) . Eur J Med Chem. 2022 Feb 5;229:114051.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1431727-00-2]