BLK-IN-2

CAT: 0804-HY-144288-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-144288-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BLK-IN-2 (compound 25) is a potent and selective irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), with an IC50 of 5.9 nM. BLK-IN-2 also inhibits BTK (IC50=202.0 nM) . BLK-IN-2 shows potent antiproliferative activities against several lymphoma cells[1].
CAS Number
[2694871-86-6]
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/blk-in-2.html
Purity
98.61
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C=NC=C2)C=C1)NC3=CC=C(C)C(C(NC4=CN=C(NC5=CC=CC(NC6CCN(C(/C=C/CN(C)C)=O)CC6)=C5)N=C4)=O)=C3
Molecular Formula
C39H41N9O3
Molecular Weight
683.80
References & Citations
[1]Fu T, et, al. Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK) . Eur J Med Chem. 2022 Feb 5;229:114051.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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