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AD013

CAT: 0804-HY-143888Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143888Size:1 Each
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Description
AD013 is a dual inhibitor of cACE/NEP. AD013 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD013 has the potential for providing the potent antihypertensive and cardioprotective benefits[1].
CAS Number
3010931-81-1
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ad013.html
Solubility
10 mM in DMSO
Smiles
O=C(CN[C@@H](CCC1=CC=CC=C1)C(O)=O)N2[C@H](C(O)=O)CC[C@@H]2C3=CC=C(C=C3)C
Molecular Formula
C24H28N2O5
Molecular Weight
424.49
References & Citations
[1]Arendse LB, et al. Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. J Med Chem. 2022;65 (4) :3371-3387.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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