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AD011

CAT: 0804-HY-143886Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-143886Size:1 Each
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Description
AD011 is a dual inhibitor of cACE/NEP. AD011 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD011 has the potential for providing the potent antihypertensive and cardioprotective benefits[1].
CAS Number
[3010931-91-3]
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ad011.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)CCCC)N[C@@H](CC2=CNC3=C2C=CC=C3)C(O)=O
Molecular Formula
C27H33N3O5
Molecular Weight
479.57
References & Citations
[1]Arendse LB, et al. Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. J Med Chem. 2022;65 (4) :3371-3387.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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