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MRGPRX1 agonist 4

CAT: 0804-HY-143880Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143880Size:1 Each
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Description
MRGPRX1 agonist 4 (compound 1t) is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.1 μM. MRGPRX1 agonist 4 has good metabolic stability and oral bioavailability. MRGPRX1 agonist 4 can reduce behavioral heat hypersensitivity in a neuropathic pain model humanized MRGPRX1 mice. MRGPRX1 agonist 4 can be used for researching neuropathic pain[1].
CAS Number
2764889-60-1
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mrgprx1-agonist-4.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C1=C(C2=CC=C(C(Cl)=C2)Cl)C3=C(N=CN=C3OC4=C(C=CC=C4)OC(F)(F)F)S1)C
Molecular Formula
C23H17Cl2F3N2O2S
Molecular Weight
513.36
References & Citations
[1]Berhane I, et al. Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1) . J Med Chem. 2022;65 (4) :3218-3228.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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