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IRAK4-IN-9

CAT: 0804-HY-143485Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143485Size:1 Each
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Description
IRAK4-IN-9 (compound 73) is a potent IRAK4 inhibitor with an IC50 of 1.5 nM. IRAK4-IN-9 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer[1].
CAS Number
2681278-07-7
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/irak4-in-9.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC2=C(C=C1)C3=NC=C(C4=CN(CCC(C)C)N=N4)C(NC(C)C)=C3N2
Molecular Formula
C22H25N7
Molecular Weight
387.48
References & Citations
[1]Sabnis RW. Novel Tricyclic Heteroaryl Compounds as IRAK4 Inhibitors for Treating Cancer, Autoimmune and Inflammatory Diseases. ACS Med Chem Lett. 2022 Feb 28;13 (3) :336-337.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4

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