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FAK-IN-3

CAT: 0804-HY-143407Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143407Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FAK-IN-3 (Compound 36) is a potent inhibitor of focal adhesion kinase (FAK) . FAK-IN-3 not only decreases migration and invasion of PA-1 cells, but also reduces expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis, and no obvious adverse effects. FAK-IN-3 has the potential for the research of ovarian cancer[1].
CAS Number
2882094-29-1
UNSPSC
12352005
Target
FAK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-in-3.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C(NC2CCNCC2)=O)=CC=C1NC3=NC4=C(C(OC5=CC=CC6=C5C(CC6)=O)=N3)C=CN4
Molecular Formula
C28H28N6O4
Molecular Weight
512.56
References & Citations
[1]Wei W, et al. Design, synthesis and biological evaluation of 7- ((7H-pyrrolo[2,3-d]pyrimidin-4-yl) oxy) -2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer. Eur J Med Chem. 2022;228:113978.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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