Protease-Activated Receptor-1 antagonist 2

Protease-Activated Receptor-1 antagonist 2

• CAS Number: 1454588-34-1
• UNSPSC Description: Protease-Activated Receptor-1 antagonist 2 is an orally active protease-activated receptor-1 (PAR-1) antagonist, with an IC50 value of 7 nM. Protease-Activated Receptor-1 antagonist 2 has favorable pharmacokinetic properties which is useful in the research of cardiovascular disease (CVD), such as atherosclerosis and restenosis[1].
• Target Antigen: Protease Activated Receptor (PAR)
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/protease-activated-receptor-1-antagonist-2.html
• Solubility: 10 mM in DMSO
• Smiles: [H][C@]12[C@H]([C@@H](C(F)(C[C@]1(C(O[C@@H]2C)=O)N)F)C)/C=C/C3=CC=C(C=N3)C4=CC=CC=C4C#N
• Molecular Weight: 423.46
• References & Citations: [1]Mihirbaran Mandal, et al. Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery. J Med Chem. 2022 Apr 14;65(7):5575-5592.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported