EGFR kinase inhibitor 1

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804-HY-143246

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EGFR kinase inhibitor 1

CAS Number: 2413958-04-8
UNSPSC Description: EGFR kinase inhibitor 1 is a potent EGFR inhibitor with IC50s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively. EGFR kinase inhibitor 1 induces apoptosis and cell cycle arrest at G0/G1-phase. EGFR kinase inhibitor 1 inhibits the cell motility. EGFR kinase inhibitor 1 shows antiproliferative and anti-tumor activity[1].
Target Antigen: Apoptosis; EGFR
Type: Reference compound
Related Pathways: Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications: Cancer-Kinase/protease
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/egfr-kinase-inhibitor-1.html
Solubility: 10 mM in DMSO
Smiles: C=CC(NC1=C(C=C(C(NC2=NC(C3=CN(C4=C3C=CC=C4)C)=CC=N2)=C1)OC)N5C=CC=C5CN(C)C)=O
Molecular Weight: 521.61
References & Citations: [1]Ding S, et al. Design, synthesis and biological evaluation of novel N-(3-amino-4-methoxyphenyl)acrylamide derivatives as selective EGFRL858R/T790M kinase inhibitors. Bioorg Chem. 2022 Jan;118:105471.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Complementary Product Range

Our range of products, including EGFR kinase inhibitor 1, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

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HY-143246	EGFR kinase inhibitor 1