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N-Methyl-dosimertinib-d5

CAT: 0804-HY-142283CSSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-142283CSSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N-Methyl-dosimertinib-d5 is the deuterium labeled of N-Methyl-dosimertinib.
CAS Number
2719690-98-7
UNSPSC
12352005
Target
EGFR
Type
Isotope-Labeled Compounds
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(NC2=NC=CC(C3=CN(C([2H])([2H])[2H])C4=C3C=CC=C4)=N2)=C(OC)C=C1NC)/C=C([2H])\[2H]
Molecular Formula
C24H19D5N6O2
Molecular Weight
433.52
References & Citations
[1]Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64 (2) :925-937. |[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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