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Valategrast (hydrochloride)

CAT: 0804-HY-14189Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14189Size:1 Each
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Description
Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2].
CAS Number
828271-96-1
Product Name Alternative
R-411
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/valategrast-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(OCCN(CC)CC)[C@H](CC1=CC=C(NC(C2=C(Cl)C=CC=C2Cl)=O)C=C1)NC(C3=C(C)C=CC=C3Cl)=O.[H]Cl
Molecular Formula
C30H33Cl4N3O4
Molecular Weight
641.41
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Woodside DG, et al. Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs. 2008;22 (2) :85-100.|[2]Halland N, et al. Small Macrocycles As Highly Active Integrin α2β1 Antagonists. ACS Med Chem Lett. 2014 Jan 10;5 (2) :193-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α4β1; α4β7

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