KVI-020

• Description:

  KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC50 of 480 nM. KVI-020 can inhibits hERG, with an IC50 of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research[1].

• Product Name Alternative:

  WYE-160020

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/kvi-020.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N([C@@](C(C=C2)=CC=C2OC)([H])CN1N[S](C)(=O)=O)CCC(C=C3)=CC=C3OC

• Molecular Formula:

  C20H25N3O5S

• Molecular Weight:

  419.49

• References & Citations:

  [1]Blass BE, et al. Selective Kv1.5 blockers: development of (R) -1- (methylsulfonylamino) -3-[2- (4-methoxyphenyl) ethyl]-4- (4-methoxyphenyl) -2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia. J Med Chem. 2009 Nov 12;52 (21) :6531-4.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1000306-34-2]