Zileuton-d4

• Description:

  Zileuton-d4 is the deuterium labeled Zileuton. Zileuton (A 64077) is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H319

• Target:

  Ferroptosis; Isotope-Labeled Compounds; Lipoxygenase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  ON(C([2H])(C1=CC2=CC=CC=C2S1)C([2H])([2H])[2H])C(N)=O

• Molecular Formula:

  C11H8D4N2O2S

• Molecular Weight:

  240.31

• Precautions:

  P264-P270-P280-P305+P351+P338-P330-P501

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10|[3]Kuvibidila S, et al. Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. Ochsner|[4]Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10 (3) :e0121402

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1189878-76-9]