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Zileuton-d4

CAT: 0804-HY-14164SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14164SSize:1 mg
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Description
Zileuton-d4 is the deuterium labeled Zileuton. Zileuton (A 64077) is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties[1][2].
CAS Number
1189878-76-9
UNSPSC
12352005
Hazard Statement
H302-H319
Target
Ferroptosis; Isotope-Labeled Compounds; Lipoxygenase
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Solubility
10 mM in DMSO
Smiles
ON(C([2H])(C1=CC2=CC=CC=C2S1)C([2H])([2H])[2H])C(N)=O
Molecular Formula
C11H8D4N2O2S
Molecular Weight
240.31
Precautions
P264-P270-P280-P305+P351+P338-P330-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10|[3]Kuvibidila S, et al. Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. Ochsner|[4]Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10 (3) :e0121402
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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