Zileuton

• Description:

  Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.

• Product Name Alternative:

  A 64077; Abbott 64077

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H319, H350, H360

• Target:

  Ferroptosis; Lipoxygenase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Zileuton.html

• Purity:

  99.86

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1

• Molecular Formula:

  C11H12N2O2S

• Molecular Weight:

  236.30

• Precautions:

  H302, H319, H350, H360

• References & Citations:

  [1]Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10|[2]Kuvibidila S, et al. Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. Ochsner|[3]Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10 (3) :e0121402

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  5-LOX

• CAS Number:

  111406-87-2