M-PEG12-OH

• Description:

  M-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].

• UNSPSC:

  12352203

• Hazard Statement:

  H315, H319

• Target:

  ADC Linker; PROTAC Linkers

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/m-peg12-oh.html

• Purity:

  99.59

• Solubility:

  10 mM in DMSO

• Smiles:

  COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

• Molecular Formula:

  C25H52O13

• Molecular Weight:

  560.67

• Precautions:

  H315, H319

• References & Citations:

  [1]Kachbi-Khelfallah S, et al. Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates. Beilstein J Org Chem. 2016 Jul 4;12:1366-71.|[2]Hamura, Mika, et al. Branched monodispersed polyethylene glycol, intermediate, and method for producing same. WO 2019181984 A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Non-cleavable Linker; PEG Linkers

• CAS Number:

  [2050595-03-2]