Azido-PEG20-alcohol

CAT: 0804-HY-140805-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-140805-01Size:5 mg

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Description

Azido-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG20-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

CAS Number

1637297-21-2

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azido-peg20-alcohol.html

Solubility

10 mM in DMSO

Smiles

OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C40H81N3O20

Molecular Weight

924.08

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Chemical Information

Azido-PEG20-alcohol

CAS Number	1637297-21-2
PubChem CID	51340917
IUPAC Name	2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Molecular Formula	C40H81N3O20
Molecular Weight	924.1
XLogP	-2.4
Topological Polar Surface Area	210
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	22
Rotatable Bond Count	59
Heavy Atom Count	63
Formal Charge	0
Complexity	875

SMILES

C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)N=[N+]=[N-]

InChI

InChI=1S/C40H81N3O20/c41-43-42-1-3-45-5-7-47-9-11-49-13-15-51-17-19-53-21-23-55-25-27-57-29-31-59-33-35-61-37-39-63-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-14-50-12-10-48-8-6-46-4-2-44/h44H,1-40H2

InChIKey

FRLHZVCZJNPUMK-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1637297-21-2

CID: 51340917

Formula: C40H81N3O20

MW: 924.1

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	924.1
XLogP3	-2.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	22
Rotatable Bond Count	59
Exact Mass	923.54134198
Monoisotopic Mass	923.54134198
Topological Polar Surface Area	210 Å²
Heavy Atom Count	63
Formal Charge	0
Complexity	875
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-138456	Benzyl-PEG20-alcohol
HY-W096138-01	M-PEG20-alcohol
HY-140801-01	Azido-PEG10-alcohol
HY-140807C	Azido-PEG22-alcohol
HY-140806-01	Azido-PEG24-alcohol
HY-138457	Azido-PEG20-Boc
HY-140797-01	Azido-PEG2-alcohol
HY-141344	S-acetyl-PEG20-alcohol
HY-174893-01	Azido-PEG20-NHS ester
HY-140807B	Azido-PEG39-alcohol

Alternative Products

Catalog	Name
MBS5770368	Azido-PEG20-alcohol
GTR19261191-01	Azido-PEG20-Boc
GTR19261189-01	Benzyl-PEG20-alcohol
MBS5799105	m-PEG20-alcohol
GTR19265507-01	Azido-PEG20-NHS ester
GTR19225005-01	S-acetyl-PEG20-alcohol
BIPG1764	S-acetyl-PEG20 alcohol
BA2484-10000	Azido-PEG5-alcohol
T14413	Azido-PEG10-alcohol
572456	Azido-PEG4-alcohol

Azido-PEG20-alcohol

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