Azido-PEG1-PFP ester

• Description:

  Azido-PEG1-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/azido-peg1-pfp-ester.html

• Purity:

  95.12

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCN=[N+]=[N-]

• Molecular Formula:

  C11H8F5N3O3

• Molecular Weight:

  325.19

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PEG Linkers

• CAS Number:

  [1807505-32-3]