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Azido-PEG1-CH2CO2-NHS

CAT: 0804-HY-140763Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-140763Size:1 Each
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Description
Azido-PEG1-CH2CO2-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
1480545-09-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg1-ch2co2-nhs.html
Solubility
10 mM in DMSO
Smiles
O=C(ON1C(CCC1=O)=O)COCCN=[N+]=[N-]
Molecular Formula
C8H10N4O5
Molecular Weight
242.19
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers

Chemical Information

Azido-PEG1-CH2CO2-NHS
CAS Number1480545-09-2
PubChem CID121235812
IUPAC Name(2,5-dioxopyrrolidin-1-yl) 2-(2-azidoethoxy)acetate
Molecular FormulaC8H10N4O5
Molecular Weight242.19
XLogP0
Topological Polar Surface Area87.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count17
Formal Charge0
Complexity360
SMILES
C1CC(=O)N(C1=O)OC(=O)COCCN=[N+]=[N-]
InChI
InChI=1S/C8H10N4O5/c9-11-10-3-4-16-5-8(15)17-12-6(13)1-2-7(12)14/h1-5H2
InChIKey
KYDOCGOPXOETIG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-PEG1-CH2CO2-NHS
CAS: 1480545-09-2
CID: 121235812
Formula: C8H10N4O5
MW: 242.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight242.19
XLogP30
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass242.06511943
Monoisotopic Mass242.06511943
Topological Polar Surface Area87.3 Ų
Heavy Atom Count17
Formal Charge0
Complexity360
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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