N-(DBCO-PEG4)-N-Biotin-PEG4-NHS

N-(DBCO-PEG4)-N-Biotin-PEG4-NHS

• CAS Number: 2353409-72-8
• UNSPSC Description: N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: PROTAC Linkers
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/n-dbco-peg4-n-biotin-peg4-nhs.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCN(C(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O)CCOCCOCCOCCOCCNC(CCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O
• Molecular Weight: 1095.26
• References & Citations: [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported