DBCO-PEG6-amine (TFA)

• UNSPSC Description:

  DBCO-PEG6-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG6-amine (TFA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/dbco-peg6-amine-tfa.html

• Purity:

  99.42

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCOCCOCCN)=O.O=C(O)C(F)(F)F

• Molecular Weight:

  725.75

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported