1,1,1-Trifluoroethyl-PEG4-amine

CAT: 0804-HY-140243Size: 1 EachDry Ice: NoHazardous: No

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Description

111-Trifluoroethyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

CAS Number

1872433-72-1

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-1-1-trifluoroethyl-peg4-amine.html

Solubility

10 mM in DMSO

Smiles

NCCOCCOCCOCCOCC(F)(F)F

Molecular Formula

C10H20F3NO4

Molecular Weight

275.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Chemical Information

1,1,1-Trifluoroethyl-PEG4-amine

CAS Number	1872433-72-1
PubChem CID	119058293
IUPAC Name	2-[2-[2-[2-(2,2,2-trifluoroethoxy)ethoxy]ethoxy]ethoxy]ethanamine
Molecular Formula	C10H20F3NO4
Molecular Weight	275.27
XLogP	-0.2
Topological Polar Surface Area	62.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	12
Heavy Atom Count	18
Formal Charge	0
Complexity	181

SMILES

C(COCCOCCOCCOCC(F)(F)F)N

InChI

InChI=1S/C10H20F3NO4/c11-10(12,13)9-18-8-7-17-6-5-16-4-3-15-2-1-14/h1-9,14H2

InChIKey

JVFYELHCDPCZQY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1872433-72-1

CID: 119058293

Formula: C10H20F3NO4

MW: 275.27

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	275.27
XLogP3	-0.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	12
Exact Mass	275.13444261
Monoisotopic Mass	275.13444261
Topological Polar Surface Area	62.9 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	181
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-140379-01	1,1,1-Trifluoroethyl-PEG4-Tos
HY-130543	1,1,1-Trifluoroethyl-PEG4-azide
HY-140887	1,1,1-Trifluoroethyl-PEG4-propargyl
HY-141247-01	1,1,1-Trifluoroethyl-PEG4-alcohol
HY-140445-01	1,1,1-Trifluoroethyl-PEG4-aminooxy
HY-140250-01	Tri (Amino-PEG4-amide) -amine
HY-22335-01	Amino-PEG4-C2-amine
HY-140250A	Tri (Amino-PEG4-amide) -amine (TFA)
HY-114670-01	Propargyl-PEG4-amine
HY-W190922	Mal-PEG4-amine

Alternative Products

Catalog	Name
T13986-01	1,1,1-Trifluoroethyl-PEG4-amine
SXC73535	1,1,1-Trifluoroethyl-PEG4-azide
T13987-01	1,1,1-Trifluoroethyl-PEG4-aminooxy
GTR19226825-01	1,1,1-Trifluoroethyl-PEG4-alcohol
GTR19226820-01	1,1,1-Trifluoroethyl-PEG4-Tos
T17318-01	1,1,1-Trifluoroethyl-PEG4-propargyl
MD133006-4	1, 1, 1-Trifluoroethyl-PEG4-N3
7220/25	A 410099.1 amide-PEG4-amine
1868-1g	Azide-PEG4-amine, 1 g
2682-1g	Biotin-PEG4-amine, 1 g

1,1,1-Trifluoroethyl-PEG4-amine

Chemical Information

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