PLAP-IN-1

• Description:

  PLAP-IN-1 is a potent (IC50 = 32 nM) and selective PLAP inhibitor, with no detectable inhibition of tissue non-specific alkaline phosphatase (TNAP) activity.

• UNSPSC:

  12352005

• Target:

  Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/plap-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C(OC)C(Cl)=CC(C2=CC=CC(C[C@@H](NC(C3=NNC(C4=CC=C(C)O4)=C3)=O)C(O)=O)=C2)=C1

• Molecular Formula:

  C25H21Cl2N3O5

• Molecular Weight:

  514.36

• References & Citations:

  [1]Bassi G, et al. Specific Inhibitor of Placental Alkaline Phosphatase Isolated from a DNA-Encoded Chemical Library Targets Tumor of the Female Reproductive Tract. J Med Chem. 2021 Nov 11;64 (21) :15799-15809.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2857113-78-9]