Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium)

Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium)

• CAS Number: 2611373-74-9
• UNSPSC Description: Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo. Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: HIV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/tenofovir-c3-o-c12-trimethylsilylacetylene-ammonium.html
• Solubility: 10 mM in DMSO
• Smiles: C[Si](C)(C)C#CCCCCCCCCCCCCOCCCOP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)([O-])=O.[NH4+]
• Molecular Weight: 626.84
• References & Citations: [1]Pribut N, et al. ω-Functionalized Lipid Prodrugs of HIV NtRTI Tenofovir with Enhanced Pharmacokinetic Properties. J Med Chem. 2021 Sep 9;64(17):12917-12937.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported