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Dolastatinol

CAT: 0804-HY-139625Size: 1 EachDry Ice: NoHazardous: No
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Description
Dolastatinol is a synthetic analog of dolastatin 10 and low nanomolar inhibitor of tubulin polymerization.
CAS Number
2759918-83-5
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dolastatinol.html
Solubility
10 mM in DMSO
Smiles
OCC1=CSC([C@H](CC2=CC=CC=C2)NC([C@@H](C)[C@@H]([C@]3([H])N(CCC3)C(C[C@H](OC)[C@H]([C@H](C)CC)N(C)C([C@@H](C(C)C)NC([C@H](N(C)C)C(C)C)=O)=O)=O)OC)=O)=N1
Molecular Formula
C43H70N6O7S
Molecular Weight
815.12
References & Citations
[1]Gutman H, et al. Discovery of Dolastatinol: A Synthetic Analog of Dolastatin 10 and Low Nanomolar Inhibitor of Tubulin Polymerization. ACS Med Chem Lett. 2021 Sep 7;12 (10) :1596-1604.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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