Dolastatin 10

• Description:

  Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

• Product Name Alternative:

  DLS 10; NSC 376128

• UNSPSC:

  12352209

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Payload; Microtubule/Tubulin

• Type:

  Natural Products

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Dolastatin-10.html

• Purity:

  98.11

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)C)=O)OC)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3

• Molecular Formula:

  C42H68N6O6S

• Molecular Weight:

  785.09

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Pitot HC, et al. Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res. 1999 Mar;5 (3) :525-31.|[2]Pettit GR, et al. Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications ofdolastatin 10. J Nat Prod. 2011 May 27;74 (5) :962-8.|[3]Brentuximab vedotin. Drugs R D. 2011;11 (1) :85-95.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 2

• Isoform:

  Auristatin

• CAS Number:

  [110417-88-4]