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MRTX849 ethoxypropanoic acid

CAT: 0804-HY-139403Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139403Size:1 Each
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Description
MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2. LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (IC50s between 0.25 and 0.76 μM)[2].
CAS Number
2561529-98-2
UNSPSC
12352005
Target
Ras; Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mrtx849-ethoxypropanoic-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(C2=C3CCN(CC3=NC(OC[C@@H]4CCCN4CCCOCCC(O)=O)=N2)C5=CC=CC6=C5C(Cl)=CC=C6)C[C@@H]1CC#N)C(F)=C
Molecular Formula
C37H43ClFN7O5
Molecular Weight
720.23
References & Citations
[1]Bond MJ, et al. Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs. ACS Cent Sci. 2020;6 (8) :1367-1375.|[2]De Vita E, et al. The Missing Link between (Un) druggable and Degradable KRAS. ACS Cent Sci. 2020;6 (8) :1281-1284.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

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