Pomalidomide 4'-PEG6-azide

Pomalidomide 4'-PEG6-azide

• CAS Number: 2624181-62-8
• UNSPSC Description: Pomalidomide 4'-PEG6-azide (compound 33e) is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pomalidomide-4-peg6-azide.html
• Solubility: 10 mM in DMSO
• Smiles: [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O
• Molecular Weight: 606.62
• References & Citations: [1]Lailiang Qu, et al. Discovery of PT-65 as a highly potent and selective Proteolysis-targeting chimera degrader of GSK3 for treating Alzheimer's disease. Eur J Med Chem. 2021 Dec 15:226:113889.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported