Norgestimate-d6

• Description :

  Norgestimate-d6 is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2]. Norgestimate-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352211

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Isotope-Labeled Compounds; Progesterone Receptor

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Others; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Solubility :

  10 mM in DMSO

• Smiles :

  CC[C@@]12[C@](C#C)(CC[C@@]1([H])[C@@]3([H])[C@]([C@]4([2H])C(C([2H])([2H])C3)=C([2H])/C(C([2H])([2H])C4)=N/O)([H])CC2)OC(C)=O

• Molecular Formula :

  C23H25D6NO3

• Molecular Weight :

  375.53

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Stanczyk FZ, et al. All progestins are not created equal. Steroids. 2003 Nov;68 (10-13) :879-90.|[3]Phillips A, et al. Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992 Oct;167 (4 Pt 2) :1191-6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1263194-12-2]