Norgestimate

• Description:

  Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2]. Norgestimate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H361

• Target:

  Progesterone Receptor

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/norgestimate.html

• Concentration:

  10mM

• Purity:

  99.57

• Solubility:

  DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  C#C[C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])CCC4=C/C(CC[C@]4([H])[C@@]3([H])CC[C@]12CC)=N/O

• Molecular Formula:

  C23H31NO3

• Molecular Weight:

  369.50

• Precautions:

  H302, H315, H319, H361

• References & Citations:

  [1]Stanczyk FZ, et al. All progestins are not created equal. Steroids. 2003 Nov;68 (10-13) :879-90.|[2]Phillips A, et al. Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992 Oct;167 (4 Pt 2) :1191-6.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  35189-28-7