Z-LLF-CHO

• Description :

  Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM) . Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor[1][2].

• Product Name Alternative :

  Z-Leu-Leu-Phe-CHO

• UNSPSC :

  12352209

• Target :

  Proteasome

• Type :

  Peptides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/z-llf-cho.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N[C@H](C=O)CC1=CC=CC=C1)[C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O

• Molecular Formula :

  C29H39N3O5

• Molecular Weight :

  509.64

• References & Citations :

  [1]Orlowski M, et al. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids. Biochemistry. 1993 Feb 16;32 (6) :1563-72.|[2]Ding L, et al. Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells. Int J Biochem Cell Biol. 2005 Sep;37 (9) :1881-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [133429-58-0]