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Penehyclidine

CAT: 0804-HY-142119Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-142119Size:1 Each
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Description
Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2].
CAS Number
87827-02-9
UNSPSC
12352005
Target
MAChR; NF-κB
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/penehyclidine.html
Solubility
10 mM in DMSO
Smiles
OC(COC1CN2CCC1CC2)(C3CCCC3)C4=CC=CC=C4
Molecular Formula
C20H29NO2
Molecular Weight
315.45
References & Citations
[1]Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885.|[2]Xiao HT, et al. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 2012;6:317-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR1; mAChR3; NF-κB

Alternative Products

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