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LY 344864 hydrochloride

CAT: 0804-HY-13788BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13788BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY 344864 hydrochloride is a selective, orally active 5-HT1F receptor agonist with a Ki of 6 nM. LY 344864 hydrochloride is a full agonist producing an effect similar in magnitude to serotonin itself. LY 344864 hydrochloride can cross the blood brain barrier to some extent[1].
CAS Number
1217756-94-9
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY_344864_hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC2=C(NC3=C2C[C@H](N(C)C)CC3)C=C1)C4=CC=C(F)C=C4.[H]Cl
Molecular Formula
C21H23ClFN3O
Molecular Weight
387.88
References & Citations
[1]Phebus LA, et al. Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Sci. 1997;61 (21) :2117-26.|[2]Scholpa NE, et al. 5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease. Br J Pharmacol. 2018 Jan;175 (2) :348-358.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; lactoferrin; mLAG-3; MUC3; α adrenergic receptor; α-1 microglobulin

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