GTPγS (tetralithium)

GTPγS (tetralithium)

• CAS Number: 94825-44-2
• UNSPSC Description: GTPγS (tetralithium) (Guanosine 5'-[γ-thio]triphosphate (tetralithium)) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS (tetralithium) to couple with G- protein α, to study its effect on kinase activity. GTPγS (tetralithium) acts as a component of lysis buffer[1][2][3][4].
• Target Antigen: GLUT
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: others
• Assay Protocol: https://www.medchemexpress.com/gtpγs-tetralithium.html
• Purity: 96.04
• Solubility: H2O : ≥ 100 mg/mL
• Smiles: O[C@H]1[C@@H](O)[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O[C@@H]1COP(OP(OP(S[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
• Molecular Weight: 562.98
• References & Citations: [1]Julie G Hensler, et al. Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration. Neuropsychopharmacology. 2002 May;26(5):565-73.|[2]Pilar Sánchez-Blázquez, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009 Sep;21(9):1444-54.|[3]Xufeng Wu, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002 May;13(5):1735-49.|[4]Li-Bin Liu, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003 Aug 8;278(32):30157-69. doi: 10.1074/jbc.M301511200.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported