TML-6-d3

• UNSPSC Description:

  TML-6-d3 is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-

• Target Antigen:

  Amyloid-β; Isotope-Labeled Compounds; Keap1-Nrf2; mTOR; NF-κB

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Neuronal Signaling;NF-κB;Others;PI3K/Akt/mTOR

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C=C(C=C1)/C=C/C(C(C([2H])([2H])[2H])(C(/C=C/C2=CC=C(C(OC)=C2)OC)=O)CC(N(CC)CC)=O)=O)OC

• Molecular Weight:

  526.64

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ih-Jen Su, et al. A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. Int J Mol Sci. 2020 Jul 30;21(15):5459.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2673270-28-3