Chrysamine G

• UNSPSC Description:

  Chrysamine G, a carboxylic acid analogue of Congo Red, can be used as a probe of amyloid deposition in Alzheimer's disease. Chrysamine G also can inhibit Aβ-induced toxicity in PC12 cells[1][2].

• Target Antigen:

  Amyloid-β

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/chrysamine-g.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O[Na])C1=C(O)C=CC(/N=N/C2=CC=C(C3=CC=C(/N=N/C4=CC(C(O[Na])=O)=C(O)C=C4)C=C3)C=C2)=C1

• Molecular Weight:

  526.41

• References & Citations:

  [1]Klunk WE, et, al. Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe. Neurobiol Aging. Jul-Aug 1995;16(4):541-8.|[2]Klunk WE, et, al. Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Life Sci. 1998;63(20):1807-14.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  6472-91-9