Ganciclovir-d5

CAT: 0804-HY-13637SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13637SSize:1 mg
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Description
Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) [1][2][3].
CAS Number
[1189966-73-1]
Product Name Alternative
BW 759-d5; 2'-Nor-2'-deoxyguanosine-d5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; CMV; HSV; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Field of Research
Infection
Purity
98.6
Solubility
10 mM in DMSO
Smiles
O=C1N=C(NC2=C1N=CN2COC([2H])(C([2H])(O)[2H])C([2H])(O)[2H])N
Molecular Formula
C9H8D5N5O4
Molecular Weight
260.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Maggs DJ, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65 (4) :399-403.|[3]Boujemla I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016;132:111-115.|[4]Fletcher CV, et al. Evaluation of ganciclovir for cytomegalovirus disease. DICP. 1989 Jan;23 (1) :5-12.|[5]Matthews T, et al. Antiviral activity and mechanism of action of ganciclovir. Rev Infect Dis. 1988 Jul-Aug;10 Suppl 3:S490-4.|[6]Duan J, Paris W, Kibler P, Bousquet C, Liuzzi M, Cordingley MG. Dose and duration-dependence of ganciclovir treatment against murine cytomegalovirus infection in severe combined immunodeficient mice. Antiviral Res. 1998;39 (3) :189-197.|[7]Faulds D, et al. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs. 1990;39 (4) :597-638.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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