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Simvastatin Acyl-β-D-glucuronide

CAT: 0804-HY-136344-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-136344-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].
CAS Number
463962-56-3
UNSPSC
12352005
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/simvastatin-acyl-β-d-glucuronide.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C)(C)CC)O[C@@H](C1)[C@@]([C@H]2CC[C@@H](O)C[C@@H](O)CC(O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)C(O)=O)=O)([H])C(C=C[C@@H]2C)=C[C@@H]1C
Molecular Formula
C31H48O12
Molecular Weight
612.71
References & Citations
[1]Prueksaritanont T, Subramanian R, Fang X, et al. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos. 2002;30 (5) :505‐512.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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