Ibuprofen acyl-β-D-glucuronide

• UNSPSC Description:

  Ibuprofen acyl-β-D-glucuronide (Ibuprofen glucuronide) is a selective TRPA1 antagonis. Ibuprofen acyl-β-D-glucuronide reduces AITC-evoked calcium response with an IC50 value of 60μM[1].

• Target Antigen:

  Endogenous Metabolite; TRP Channel

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/1-_alpha-Methyl-4-_2-methylpropyl_benzeneacetate_-beta-D-Glucopyranuronic_acid.html

• Smiles:

  CC(C(O[C@@H]1O[C@H](C(O)=O)[C@H]([C@@H]([C@H]1O)O)O)=O)C2=CC=C(C=C2)CC(C)C

• Molecular Weight:

  382.40

• References & Citations:

  [1]Francesco De Logu, et al. The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel. Pharmacol Res. 2019 Apr:142:127-139.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  115075-59-7