Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester

• UNSPSC Description:

  Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• Target Antigen:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fmoc-nh-azide-peg4-l-lysine-pfp-ester.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)C(NC(OCC2C(C=CC=C3)=C3C4=C2C=CC=C4)=O)CCCCNC(CCOCCOCCOCCOCCN=[N+]=[N-])=O

• Molecular Weight:

  807.76

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported