Androsta-1,4,6-triene-3,17-dione

• UNSPSC Description:

  Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].

• Target Antigen:

  Cytochrome P450

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/androsta-1-4-6-triene-3-17-dione.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]1([C@](CC2)([H])[C@]3([H])C=CC4=CC(C=C[C@]4(C)[C@@]3([H])CC1)=O)C2=O

• Molecular Weight:

  282.38

• References & Citations:

  [1]Covey DF, et al. Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity. Endocrinology. 1981 Apr;108(4):1597-9.|[2]Brodie AM, et al. Antifertility effects of an aromatase inhibitor, 1,4,6-androstatriene-3, 17-dione. Endocrinology. 1979 Jan;104(1):118-21.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  633-35-2