Methyltetrazine-PEG4-aldehyde

Methyltetrazine-PEG4-aldehyde

• UNSPSC Description: Methyltetrazine-PEG4-aldehyde is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Methyltetrazine-PEG4-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/methyltetrazine-peg4-aldehyde.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=NN=C(C2=CC=C(CNC(CCOCCOCCOCCOCCNC(C3=CC=C(C([H])=O)C=C3)=O)=O)C=C2)N=N1
• Molecular Weight: 580.63
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported