Cemadotin

• Description :

  Cemadotin (LU103793) is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer[1][2].

• Product Name Alternative :

  LU103793 (free base)

• UNSPSC :

  12352209

• Target :

  Microtubule/Tubulin; Mitosis

• Type :

  Peptides

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cemadotin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)[C@H](N(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC3=CC=CC=C3)=O)=O)=O)=O)=O

• Molecular Formula :

  C35H56N6O5

• Molecular Weight :

  640.86

• References & Citations :

  [1]Jordan MA, et al. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 Dec 15;37 (50) :17571-8.|[2]Bernardes GJ, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed Engl. 2012 Jan 23;51 (4) :941-4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [159776-69-9]