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Cemadotin hydrochloride

CAT: 0931-T70235-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70235-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
172837-41-1
Target
Others, Microtubule Associated
Related Pathways
Others, Cytoskeletal Signaling
Bioactivity
Cemadotin hydrochloride is the salt from of Cemadotin (free base), also known as, LU103793, a mitosis inhibitor potentially for the treatment of solid tumours. Cemadotin is also a synthetic derivative of Dolastatin 15, an antiproliferative compound which was isolated from the mollusk Dolabella auricularia. Like Dolastatin 15, LU103793 is highly cytotoxic in vitro (IC50 = 0.1 nM) . LU103793 inhibits microtubule polymerization in a concentration-dependent manner (IC50 = 7 microM) . Treatment with this compound also induced depolymerization of preassembled microtubules. Cell cycle analysis of tumor cell lines treated with LU103793 indicated a block in the G2-M phase.
Smiles
Cl.CC(C)[C@H](NC(=O)[C@H](C(C)C)N(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCc1ccccc1
Molecular Formula
C35H57ClN6O5
Molecular Weight
677.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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