Milameline

CAT: 0804-HY-135460Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-135460Size:1 Each

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Description

Milameline (CI-979; RU35926) is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine. Milameline can be used for the study of Alzheimer’s Disease[1].

CAS Number

139886-32-1

Product Name Alternative

CI-979; RU35926

UNSPSC

12352005

Hazard Statement

H301

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/milameline.html

Solubility

10 mM in DMSO

Smiles

CO/N=C/C1=CCCN(C)C1

Molecular Formula

C8H14N2O

Molecular Weight

154.21

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Heidrich, A., and M. Rösler. "Milameline: nonselective, partial muscarinic receptor agonist for the treatment of Alzheimer's disease?." CNS Drug Reviews (1999) .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

MAChR1; mAChR2; mAChR3; mAChR4

Alternative Products

Catalog	Name
T70772-01	Milameline
B7123-10	Milameline hydrochloride
GTR19241512-01	Milameline hydroiodide

Milameline

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